Sleep8 | 90 Capsules

SLEEP8 is elaborated with ingredients attributed with anxiolytic, sedative, relaxing and hypnotic effects, which act naturally in synergy to help one fall asleep and recover refreshing sleep. They act on the CNS, binding to GABA-ergic receptors, decreasing anxiety and nervousness without the usual side effects of hypnotic medications. SLEEP8 increases REM sleep, improving the duration and quality of sleep. It acts on the circadian rhythm, regulating periods of wakefulness and sleep. PASSION FLOWER: The active part of this plant lies in the uppermost pistils. Passion flower contains flavonoids (vitexin, isovitexin, orientin), flavones and flavonols such as apigenin, luteolin and quercetol, alpha-pyrone derivatives (maltol and ethyl maltol), coumarins and phenolic acids, among other compounds. Experimental studies show its sedative and anxiolytic action. The results suggest that it strengthens and prolongs sleep, and in a study carried out on patients with general anxiety disorders, passion flower was proven effective. It is not known exactly which compound(s) are responsible for this activity, although it is possibly due to a synergic effect between its diverse components(1-3,6). HOPS: For therapy, the female flower parts are used, which contain a resin rich in bitter compounds, humulones and lupulones. They also possess essential oil, mineral salts, tannins and different types of flavonoids (flavones, isoflavones and chalcones). The effect of hops on the central nervous system, especially in sleep alterations, has been well studied, above all in experimental trials. It has sedative, anxiolytic and sleep-inducing activity. It contains 8-prenylnaringenin, a flavanone with powerful oestrogenic activity, making it useful in cases of sleep alteration associated with menopause(4-6). SKULLCAP: The dried root of skullcap has been used traditionally in Chinese medicine. Among its active principles are flavonoids such as baicalin and baicalein, wogonin and wogonoside. There is scientific evidence associating skullcap with anxiolytic and wakefulness-sleep phase regulating effects, as it seems that these flavonoids modulate the GABA(A) receptor which is involved in neuron balance(7-10). CHAMOMILE: The active part is the flower which contains essential oil and flavonoids, among which apigenin and sesquiterpene lactones stand out. Its mild sedative effect and anxiolytic action have been well studied, and it is apigenin that is responsible for binding to benzodiazepine receptors, causing this effect. Different revised monographs point out that chamomile is a good option for the treatment of nervous disorders such as anxiety and mild insomnia(11,12). PANAX NOTOGINSENG: Widely used in traditional Chinese medicine, this is known as Tienchi ginseng. Among its active components are ginsenosides, polysaccharides and saponins. Scientific literature on its anti-inflammatory activity, its cardioprotective action and its phytoestrogenic capacity. Its use for improving mental function and treating insomnia and anxiety has also been described. A recent study showed that this improvement was related to the saponin content of the plant. Concerning mental function, it improves memory and learning ability upon protecting neurons from oxidative damage and exerting a neuroregenerative action, which could compensate for the neuron damage that occurs in certain types of dementia(13,14,15). MAGNESIUM: The adult body contains between 20 and 28 grams of magnesium, of which about 60% is found in the bones, 26% in muscles and the rest in soft tissue and bodily fluids. Extracellular magnesium intervenes in neuromuscular transmission and proper cardiac function, and has a primordial role in muscle relaxation. Intracellular magnesium forms part of the bone matrix. It is an essential macroelement for the assimilation of calcium and vitamin C. It is also considered an anti-stress mineral since diverse studies have shown that it decreases anxiety, and given that it relaxes muscles, it can be used for treating chronic stress and improving resistance to fatigue. Its nutritional deficit causes anxiety, fatigue, insomnia and trembling, among other manifestations. In our formula, magnesium has been joined to 2 glycine molecules to increase its absorption and bioavailability, so its absorption is 4 times faster than that of other magnesium formulas(16,17). CATNIP: The parts of this plant used for therapeutic purposes are the leaves and floral tips. It is found in Europe and North America. Among its main components are flavonoids, phenolic acids and terpenoids, which have been described as responsible for its mild sedative action. In another study, it was the nepetalactones contained in the plant that were found to be responsible for its sedative effect(18,19). MELATONIN: This hormone, found naturally in the body, is generally used to adjust the inner clock, regulating wakefulness-sleep cycles. It is used to treat the inability to fall asleep as well as insomnia associated with attention deficit and hyperactivity disorder (20,21).

Ingredients: Magnesium bisglycinate, passionflower flower extract (Passiflora incarnata), hops strobile extract (Humulus lupulus), skullcap root extract (Scutellaria lateriflora), chamomile flower extract (Matricaria chamomilla), qiye shen’an pian leaf extract (Panax notoginseng), catnip herb top (Nepeta cataria), vegetable magnesium stearate and silicon dioxide (anticaking agent), melatonin, vegetable capsule (glacing agent: hydroxypropylmethylcellulose; purified water).

Nutritional information:
Passionflower (4% flavonoids) 35 mg
Hops (3,5% flavonoids) 35 mg
Skullcap (12,5% flavonoids) 35 mg
Chamomile (5% flavonoids) 35 mg
Panax notoginseng 25 mg
Catnip 15 mg
Melatonin 0,5 mg
Magnesium 20 mg

Usage guide:
Do not use if you are pregnant, breastfeeding, taking immunosuppressive drugs or cyclosporine, or allergic to plants of the Asteraceae/Compositae/daisy family. Should not be given to children under the age of 12 years. Consult a health care practitioner prior to use if you have depression, a hormonal disorder, diabetes, liver disease, kidney disease, cancer, endometriosis, cerebral palsy, seizure disorders, migraine, or hypertension. Consult a health-care practitioner if you are treated with oral anticoagulants, antidiabetic or antiplatelet medication because a dose adjustment might be necessary. Concomitant use with other sedative/hypnotic and/or anxyolytic medication can enhance the sedative effect for which it should be avoided without supervision. Interaction between Panax Notoginseng and the MAOIs have been described. Simultaneous use of SLEEP8 and alcohol or antidepressant medications can enhance the sedative effect.

https://www.proactivedispensary.com/sleep8-90-capsules-new-roots-herbal